An Analytical Study of the Redox Behavior of 1,10‐Phenanthroline‐5,6‐dione, its Transition‐Metal Complexes, and its N‐Monomethylated Derivative with regard to their Efficiency as Mediators of NAD(P)+ Regeneration

摘要: The synthesis as well the chemical and electrochemical properties of homoleptic heteroleptic (trispyridyl-methylamine coligand) transition-metal complexes (Ru Co) 1,10-phenanthroline-5,6-dione (PD) its N-monomethylated derivative (PDMe+) are described. In particular, their ability to abstract hydride ions was studied. Electrochemical investigations with cyclic voltammetry, rotating disk electrode experiments, spectroelectrochemical methods at different pH values gave an insight into complex electrochemistry compounds described, which is strongly influenced by a hydration pre-equilibrium. electrochemically active quinone form can be reduced hydroquinone state in acidic solution transition-metal-stabilized semi-quinone states for neutral basic solutions, whereas PDMe+ both solutions. also chemically, efficient catalysts indirect oxidation enzymatic cofactor NAD(P)H. For aerobic NAD(P)H oxidation, up 900 turnovers per hour observed, achievement yet reached other catalyst systems.