Mechanisms of cell height changes that mediate epithelial invagination.

摘要: Epithelial invagination is a morphogenetic process that converts flat cell sheets into tubular structures and contributes to the formation of three-dimensional organs during development. Because cells in have smaller apical than basal surfaces, constriction thought be critical for epithelial invagination. In addition, also accompanied by elongation, followed shortening expansion. While mechanisms involved been well-characterized, recent technical advances are just beginning unravel height control, which include cytoskeletal changes, cortical tension generation, adhesion, cytoplasmic flow. Furthermore, changes associated with mitosis apoptosis recently shown contribute To develop comprehensive understanding invagination, it important elucidate mediate shape facilitate their coordination. this review, we summarize field, focusing on control height.