Noradrenaline-selective versus serotonin-selective antidepressant therapy: differential effects on social functioning

摘要: The outcome of antidepressant therapy in terms social functioning was evaluated a randomized, placebo-controlled, double-blind study comparing the selective noradrenaline reuptake inhibitor (NARI), reboxetine, with serotonin (SSRI) fluoxetine. Of 381 patients major depression participating study, 302 were assessed using new self-rating Social Adaptation Self-evaluation Scale (SASS). Mean SASS total score at last assessment superior (p < 0.05) to placebo for both reboxetine and Moreover, Evaluation sensitivity change individual items by point-biserial correlation analysis showed significant between improvement item treatment all but one reboxetine-placebo comparison. In fluoxetine-placebo comparison, evident only 12 21 items. Direct comparison fluoxetine revealed nine items, favour reboxetine. association maximal six mainly related negative self-perception active behaviour. subset remission (n = 91), mean that 0.05). Point-biserial most sensitive under population did so (17 items) or (nine remission. reboxetine-fluoxetine 14 treatment. conclusion, while motivation behaviour are significantly affected noradrenergic serotonergic treatment, seems particularly effective improving towards action, resulting better quality functioning.