DOCA sensitive pendrin expression in kidney, heart, lung and thyroid tissues.
作者： Lisann Pelzl , Tatsiana Pakladok , Ganesh Pathare , Hajar Fakhri , Diana Michael
DOI: 10.1159/000343337
关键词:
摘要: Background/Aims: Pendrin (SLC26A4), a transporter accomplishing anion exchange, is expressed in inner ear, thyroid gland, kidneys, lung, liver and heart. Loss or reduction of function mutations SLC26A4 underlie Pendred syndrome, disorder invariably leading to hearing loss with enlarged vestibular aqueducts some patients hypothyroidism goiter. Renal pendrin expression up-regulated by mineralocorticoids such as aldosterone deoxycorticosterone (DOCA). Little known about the impact on extrarenal tissues. Methods: The present study utilized RT-qPCR Western blotting quantify transcript levels protein abundance Slc26a4 murine kidney, thyroid, heart lung prior following subcutaneous administration 100 mg/kg DOCA. Results: compared Gapdh were significantly increased DOCA treatment heart, thyroid. Accordingly was again Conclusion: observations reveal mineralocorticoid sensitivity lung.
core.ac.uk
uzh.ch
karger.com 
sci-hub.se 参考文章(104)
Vladimir Pech, Susan M. Wall, Pendrin and sodium channels: relevance to hypertension. Journal of Nephrology. ,(2010)
Luciene R Carraro-Lacroix, Gerhard Malnic, Acid-base transport by the renal distal nephron. Journal of Nephrology. ,(2010)
L. Fugazzola, L. Persani, D. Calebiro, P. Porazzi, M. Marinò, S. Lisi, A. Grindati, G. Bottà, M. Bonomi, D. De Nittis, Absence of primary hypothyroidism and goiter in Slc26a4 (-/-) mice fed on a low iodine diet Journal of Endocrinological Investigation. ,vol. 34, pp. 593- 598 ,(2011) , 10.3275/7262
David Pearce, Aditi Bhargava, Timothy J Cole, Aldosterone: Its Receptor, Target Genes, and Actions Vitamins & Hormones. ,vol. 66, pp. 29- 76 ,(2003) , 10.1016/S0083-6729(03)01002-1
Byung Yoon Choi, Julie Muskett, Kelly A. King, Christopher K. Zalewski, Thomas Shawker, James C. Reynolds, John A. Butman, Carmen C. Brewer, Andrew K. Stewart, Seth L. Alper, Andrew J. Griffith, Hereditary hearing loss with thyroid abnormalities. Advances in oto-rhino-laryngology. ,vol. 70, pp. 43- 49 ,(2011) , 10.1159/000322469
O. C. Meijer, Coregulator Proteins and Corticosteroid Action in the Brain Journal of Neuroendocrinology. ,vol. 14, pp. 499- 505 ,(2002) , 10.1046/J.1365-2826.2002.00795.X
Florian Lang, Michael Föller, Karl Lang, Philipp Lang, Markus Ritter, Alexey Vereninov, Ildiko Szabo, Stephan M. Huber, Erich Gulbins, Cell volume regulatory ion channels in cell proliferation and cell death. Methods in Enzymology. ,vol. 428, pp. 209- 225 ,(2007) , 10.1016/S0076-6879(07)28011-5
DC Winter, MF Schneider, GC O'sullivan, BJ Harvey, JP Geibel, Rapid effects of aldosterone on sodium-hydrogen exchange in isolated colonic crypts. The Journal of Membrane Biology. ,vol. 170, pp. 17- 26 ,(1999) , 10.1007/S002329900534
Fabian R. Reimold, John F. Heneghan, Andrew K. Stewart, Israel Zelikovic, David H. Vandorpe, Boris E. Shmukler, Seth L. Alper, Pendrin function and regulation in Xenopus oocytes. Cellular Physiology and Biochemistry. ,vol. 28, pp. 435- 450 ,(2011) , 10.1159/000335106
Lyubomira Ivanova, Rita Bernhardt, Ingolf Bernhardt, Nongenomic effect of aldosterone on ion transport pathways of red blood cells. Cellular Physiology and Biochemistry. ,vol. 22, pp. 269- 278 ,(2008) , 10.1159/000149805