Role of a p53 polymorphism in the development of human papillomavirus-associated cancer.
作者： Alan Storey , Miranda Thomas , Ann Kalita , Catherine Harwood , Daniela Gardiol
DOI: 10.1038/30400
关键词:
摘要: The E6 oncoprotein derived from tumour-associated human papillomaviruses (HPVs) binds to and induces the degradation of cellular tumour-suppressor protein p53. A common polymorphism that occurs in p53 amino-acid sequence results presence either a proline or an arginine at position 72. effect this on susceptibility E6-mediated has been investigated form was found be significantly more susceptible than form. Moreover, allelic analysis patients with HPV-associated tumours revealed striking overrepresentation homozygous arginine-72 compared normal population, which indicated individuals for 72 are about seven times tumorigenesis heterozygotes. arginine-encoding allele therefore represents significant risk factor development cancers.
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