Types of neurons in the enteric nervous system.

摘要: This paper, written for the symposium in honour of more than 40 years' contribution to autonomic research by Professor Geoffrey Burnstock, highlights progress made understanding organisation enteric nervous system over this time. Forty years ago, prevailing view was that neurons within gut wall were post-ganglionic parasympathetic pathways. replaced as evidence accrued are part and involved reflex integrative activities can occur even absence neuronal influence from extrinsic sources. Work Burnstock's laboratory led discovery intrinsic inhibitory with then novel pharmacology transmission, precipitated investigation neuron types system. All small intestine guinea-pig have now been identified terms their morphologies, projections, primary neurotransmitters physiological identification. In region there 14 functionally defined types, each a characteristic combination morphological, neurochemical biophysical properties. The nerve circuits underlying effects on motility, blood flow secretion mediated through constructed these neurons. simple motility reflexes known, has analysing those local control transmucosal fluid movement intestine.