Endothelial Progenitor Cell Therapy in Stroke

摘要: Stroke is a major cause of death globally, which induces irreversible neuronal and endothelial cell death. Endothelial progenitor (EPC) based therapeutics result in neovascularization the improvement vascular perfusion, benefits clinical stroke patients. Although EPC transplantation experimental models shows functional improvement, therapy patients continues to face an arduous task. In this chapter, we give brief introduction EPCs including source EPCs, methods isolation identification EPC, therapeutic potential for stroke, signaling modulating function. Furthermore, summarize molecular mechanisms action after either through differentiating into mature cells replace damaged or by enhancing trophic/regenerative support endogenous repair processes. We discuss routes modifying safety efficacy vivo. Finally, pros cons application Though EPC-based treatment holds promise regeneration, field needs more study uncover resolve unsolved problems.