Cardiovascular Changes in Patients With COVID-19 From Wuhan, China

摘要: Background: Coronavirus disease 2019 (COVID-19) is rapidly spreading and resulting in a significant loss of life around the world. However, specific information characterizing cardiovascular changes COVID-19 limited. Methods: In this single-centered, observational study, we enrolled 38 adult patients with from February 10 to March 13, 2020. Clinical records, laboratory findings, echocardiography, electrocardiogram reports were collected analyzed. Results: Of enrolled, median age was 68 years [interquartile range (IQR), 55-74] slight female majority (21, 55.3%). Nineteen (50.0%) had hypertension. Seven (33.3%) ST-T segment T wave changes, four (19%) sinus tachycardia. Twenty (52.6%) an increase ascending aorta (AAO) diameter, 22 (57.9%) left atrium (LA) size, 28 (73.7%) presented ventricular diastolic dysfunction. Correlation analysis showed that AAO diameter significantly associated C-reactive protein (r = 0.4313) creatine kinase-MB 0.0414). LA enlargement 0.4377), brain natriuretic peptide 0.7612), 0.4940), aspartate aminotransferase 0.2947). Lymphocyte count negatively -0.5329) -0.3894). Conclusions: Hypertension common comorbidity among hospitalized COVID-19, cardiac injury most complication. Changes structure function manifested mainly heart these patients. Abnormal size found be severe inflammation injury. Alternatively, aortic dilation might present before infection but characterized patient at risk for acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.