Fabrication of individual alginate-TCP scaffolds for bone tissue engineering by means of powder printing

摘要: The development of polymer-calcium phosphate composite scaffolds with tailored architectures and properties has great potential for bone regeneration. Herein, we aimed to improve the functional performance brittle ceramic by developing a promising biopolymer-ceramic network. For this purpose, two strategies, namely, direct printing powder composition consisting 60:40 mixture α/β-tricalcium (TCP) alginate or vacuum infiltration printed TCP an solution, were tracked. Results structural characterization revealed that 2.5 wt% alginate-modified powders presented uniformly distributed interfusing Mechanical results indicated significant increase in strength, energy failure reliability powder-modified content educts when compared pure TCP, as well containing 5 7.5 educts, both dry wet states. Culture human osteoblast cells on these also demonstrated improvement cell proliferation viability. While case powder-mixed scaffolds, isolated gels formed between calcium crystals, vacuum-infiltration strategy resulted covering surface internal pores scaffold thin film. Furthermore, prediction scaffolds' critical fracture conditions under more complex stress states applied Mohr criterion confirmed biomaterial tissue engineering.