Role of steroid hormones in potentiating transformation of cervical cells by human papillomaviruses
作者： Mary M. Pater , Rakesh Mittal , Alan Pater
DOI: 10.1016/0966-842X(94)90627-0
关键词:
摘要: Human papillomaviruses (HPVs) are etiologically involved in cervical neoplasia, and epidemiological evidence suggests that steroid hormones can increase the risk of this cancer HPV-infected women. Steroids interact with hormone-response elements viral long control region, enhancing HPV transcription resulting transformation cells. Subsequent malignant progression may involve virus-induced chromosomal instability, facilitating DNA integration deregulation gene expression.
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