B Cells Are Required for Generation of Protective Effector and Memory CD4 Cells in Response to Pneumocystis Lung Infection

摘要: B cell-deficient mice are susceptible to infection by Pneumocystis carinii f. sp. muris (PC). To determine whether this susceptibility is due a requirement for cells prime T cells, we compared CD4 cell responses PC in bone marrow chimeric that express MHC class II (MHCII) on all APCs (wild-type (WT) chimeras) and MHCII except (MHCII−/− chimeras). Although was rapidly cleared WT mice, levels remained high lacked cells. In addition, although were primed the draining lymph nodes of MHCII−/− number activated infiltrating lungs these reduced relative chimeras. We also adoptively transferred purified from PC-infected normal or into SCID mice. Mice received able mount response clear PC. However, had delayed failed control infection. These data indicate play vital role generation CD4+ memory lungs.