Increased lymph node harvest in patients operated on for right-sided colon cancer: a population-based study.

作者: R. Bernhoff , T. Holm , A. Sjövall , F. Granath , A. Ekbom

DOI: 10.1111/J.1463-1318.2012.03020.X

关键词:

摘要: Aim  In recent decades, the focus has been on treatment of rectal cancer with improved surgical techniques. This resulted in results for patients cancer. Recently, shifted to colon surgery introduction preoperative staging, new techniques, quality control and enhanced recovery programmes. The change operative techniques most pronounced tumours right side colon, more extensive resections proximal ligations vessels. aim this study was assess number analysed lymph nodes metastatic index (MI) operated right-sided Stockholm area between 1996 2009. Method  All January December 2009 were divided into three groups based year which they (period 1, 1996–1999; period 2, 2000–2004; 3, 2005–2009). node status analysed. Results  total, 3536 during period. There a significantly lower proportion emergency operations third time mean examined increased overall (seven 11 2 18 3; P < 0.001). A significant drop MI seen (0.25, compared 0.40 1 2; P < 0.001). Conclusion  During there an increase decrease after hemicolectomies. Further investigations are needed evaluate potential impact short-term long-term outcome.

参考文章(29)
Neal S. Goldstein, Weldon Sanford, Mary Coffey, Lester J. Layfield, Lymph Node Recovery From Colorectal Resection Specimens Removed for Adenocarcinoma:Trends Over Time and a Recommendation for a Minimum Number of Lymph Nodes to be Recovered American Journal of Clinical Pathology. ,vol. 106, pp. 209- 216 ,(1996) , 10.1093/AJCP/106.2.209
Joanne F. Chou, David Row, Mithat Gonen, Yi-Hai Liu, Deborah Schrag, Martin R. Weiser, Clinical and pathologic factors that predict lymph node yield from surgical specimens in colorectal cancer: a population-based study. Cancer. ,vol. 116, pp. 2560- 2570 ,(2010) , 10.1002/CNCR.25032
W. Hohenberger, K. Weber, K. Matzel, T. Papadopoulos, S. Merkel, Standardized surgery for colonic cancer: complete mesocolic excision and central ligation - technical notes and outcome Colorectal Disease. ,vol. 11, pp. 354- 364 ,(2009) , 10.1111/J.1463-1318.2008.01735.X
Vassiliki L. Tsikitis, David L. Larson, Bruce G. Wolff, Gregory Kennedy, Nancy Diehl, Rui Qin, Eric J. Dozois, Robert R. Cima, Survival in stage III colon cancer is independent of the total number of lymph nodes retrieved. Journal of The American College of Surgeons. ,vol. 208, pp. 42- 47 ,(2009) , 10.1016/J.JAMCOLLSURG.2008.10.013
J. Segelman, T. Singnomklao, H. Hellborg, A. Martling, Differences in multidisciplinary team assessment and treatment between patients with stage IV colon and rectal cancer. Colorectal Disease. ,vol. 11, pp. 768- 774 ,(2009) , 10.1111/J.1463-1318.2008.01648.X
G. J. Chang, M. A. Rodriguez-Bigas, J. M. Skibber, V. A. Moyer, Lymph Node Evaluation and Survival After Curative Resection of Colon Cancer: Systematic Review Journal of the National Cancer Institute. ,vol. 99, pp. 433- 441 ,(2007) , 10.1093/JNCI/DJK092
Sachin S. Kukreja, Increased Lymph Node Evaluation With Colorectal Cancer Resection Archives of Surgery. ,vol. 144, pp. 612- 617 ,(2009) , 10.1001/ARCHSURG.2009.112
A. Sjövall, T. Holm, T. Singnomklao, F. Granath, B. Glimelius, B. Cedermark, Colon cancer management and outcome in relation to individual hospitals in a defined population British Journal of Surgery. ,vol. 94, pp. 491- 499 ,(2007) , 10.1002/BJS.5455
S George, , J Primrose, R Talbot, J Smith, M Mullee, D Bailey, C du Boulay, H Jordan, Will Rogers revisited: prospective observational study of survival of 3592 patients with colorectal cancer according to number of nodes examined by pathologists. British Journal of Cancer. ,vol. 95, pp. 841- 847 ,(2006) , 10.1038/SJ.BJC.6603352