A positive role for histone acetylation in transcription factor access to nucleosomal DNA
作者： Daniel Y. Lee , Jeffrey J. Hayes , Dmitry Pruss , Alan P. Wolffe
DOI: 10.1016/0092-8674(93)90051-Q
关键词:
摘要: Acetylation of the N-terminal tails core histones directly facilitates recognition by TFIIIA 5S RNA gene within model chromatin templates. This effect is independent a reduction in extent histone-DNA interactions or change DNA helical repeat; it also whether histone tetramer octamer inhibits binding. Removal from association with nucleosomal We suggest that have major role restricting transcription factor access to and their acetylation releases this restriction directing dissociation and/or inducing configuration on allow might be expected exert influence accessibility regulatory molecules.
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