Peripheral Blood Leukocytes as a Surrogate Marker for Cisplatin Drug Resistance: Studies of Adduct Levels and the Repair Gene ERCC1
作者： Ricardo J. Parker , Miriam C. Poirier , Freida Bostick-Bruton , Justine Vionnet , Vilhelm A. Bohr
DOI: 10.1007/978-1-4613-0637-5_20
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摘要: Cisplatin and its analogs are potent chemotherapeutic agents in the treatment of ovarian cancer, testicular other malignancies. Studies by this group have shown that level platinum-DNA adduct formed leukocyte DNA is directly related to disease response cancer (Reed et al, 1987) 1988a), attained influenced persistence precursors some patients for no less than 28 days 1986). Because has been observed but not others 1986), we interested study those factors may influence persistence, whether these clinical parameters and/or subcellular cisplatin drug resistance. We assessed relative contribution a cohort with compare data measurements from same individuals.
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