A Novel G Protein-Biased and Subtype-Selective Agonist for a G Protein-Coupled Receptor Discovered from Screening Herbal Extracts.

作者: Bingjie Zhang , Simeng Zhao , Dehua Yang , Yiran Wu , Ye Xin

DOI: 10.1021/ACSCENTSCI.9B01125

关键词:

摘要: … We also thank Xiaoyan Liu, Junlin Liu, and Fangfang Zhou from iHuman Institute, and Antao Dai and Chao Zhang from Shanghai Institute of Materia Medica for technical assistance. …

参考文章(59)
I Charfi, N Audet, H Bagheri Tudashki, G Pineyro, Identifying ligand-specific signalling within biased responses: focus on δ opioid receptor ligands British Journal of Pharmacology. ,vol. 172, pp. 435- 448 ,(2015) , 10.1111/BPH.12705
Paul R. Hartig, John P. Patterson, David W. Robertson, Ilgar Abbaszade, Jeannine M. Hollis, Barry S. Brown, Lawrence W. Fitzgerald, Brian L. Largent, Gregory F. Hollis, Timothy C. Burn, Martha H. Corjay, Jung-Hui Sun, John R. Link, Paul C. Meunier, Patricia A. Valentine, Albert J. Robichaud, Possible role of valvular serotonin 5-HT(2B) receptors in the cardiopathy associated with fenfluramine. Molecular Pharmacology. ,vol. 57, pp. 75- 81 ,(2000)
Bryan L. Roth, Drugs and valvular heart disease. The New England Journal of Medicine. ,vol. 356, pp. 6- 9 ,(2007) , 10.1056/NEJMP068265
Arne Astrup, Drug Management of Obesity — Efficacy versus Safety New England Journal of Medicine. ,vol. 363, pp. 288- 290 ,(2010) , 10.1056/NEJME1004076
Jonathan D. Violin, Aimee L. Crombie, David G. Soergel, Michael W. Lark, Biased ligands at G-protein-coupled receptors: promise and progress Trends in Pharmacological Sciences. ,vol. 35, pp. 308- 316 ,(2014) , 10.1016/J.TIPS.2014.04.007
Joseph B. Blair, Deborah Kurrasch-Orbaugh, Danuta Marona-Lewicka, Medhane G. Cumbay, Val J. Watts, Eric L. Barker, David E. Nichols, Effect of ring fluorination on the pharmacology of hallucinogenic tryptamines. Journal of Medicinal Chemistry. ,vol. 43, pp. 4701- 4710 ,(2000) , 10.1021/JM000339W
Richard B. Rothman, Michael H. Baumann, Jason E. Savage, Laura Rauser, Ace McBride, Sandra J. Hufeisen, Bryan L. Roth, Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications. Circulation. ,vol. 102, pp. 2836- 2841 ,(2000) , 10.1161/01.CIR.102.23.2836
James J DiNicolantonio, Subhankar Chatterjee, James H O'Keefe, Pascal Meier, Lorcaserin for the treatment of obesity? A closer look at its side effects Open Heart. ,vol. 1, ,(2014) , 10.1136/OPENHRT-2014-000173
Min He, Xinjian Yan, Jiaju Zhou, Guirong Xie, Traditional Chinese medicine database and application on the Web. Journal of Chemical Information and Computer Sciences. ,vol. 41, pp. 273- 277 ,(2001) , 10.1021/CI0003101
Herbert Y. Meltzer, Bryan L. Roth, Lorcaserin and pimavanserin: emerging selectivity of serotonin receptor subtype–targeted drugs Journal of Clinical Investigation. ,vol. 123, pp. 4986- 4991 ,(2013) , 10.1172/JCI70678