Repeated recall of learned immunosuppression: evidence from rats and men.

摘要: Abstract Akin to other physiological responses, the immune system can be modified, via Pavlovian or behavioral conditioning. It is unknown, however, whether and what extent learned responses repeatedly recalled over time. Here we demonstrate in both rats humans that repeated contingent pairing of a novel taste (conditioned stimulus, CS) together with immunosuppressive drug cyclosporine A as unconditioned stimulus (US) leads acquisition immunosuppression. Sole presentation CS caused significant inhibition interleukin (IL)-2 interferon (IFN)-γ production by rat splenic T cells human peripheral lymphocytes, closely mimicking effect drug. More importantly, comparable suppression cytokine was also observed after second, unreinforced exposure separated from first evocation an interval 6 (rats) 11 (humans) days, respectively. Together, our findings immunosuppression animals humans, which important prerequisite for implementation conditioning paradigms supportive therapy.