Differential patterns of apoptosis in resolving and nonresolving bacterial pneumonia.

摘要: Infection with either Streptococcus sanguis or pneumoniae type 25 causes acute pneumonitis in rats. Pneumonia caused by S. resolves over the course of 8 d, whereas pneumonia progesses to fibrosis. To examine role apoptosis these models, we performed assays terminal deoxynucleotidyltransferase–uridine nucleotide end-labeling technique on tissue sections from rat lungs at various times, and quanitified results image analysis. Apoptosis was a feature both resolving stages pneumnia. The pattern extent were similar models during stage, number apoptotic nuclei increased through 4 d after infection. Although there differences cellular 2 infection, same models. After major observed. In model, limited primarily ...