Current Progress in Human Epidermal Growth Factor Receptor 2 Targeted Therapies in Esophagogastric Cancer
作者： Yelena Y. Janjigian , Maria Ignez Braghiroli
DOI: 10.1016/J.SOC.2016.10.005
关键词:
摘要: Esophagogastric cancer is a worldwide health problem. The addition of the epidermal growth factor receptor 2 (HER2)-directed antibody trastuzumab to chemotherapy increased overall survival patients with metastatic HER2-positive esophagogastric cancer. This article discusses available data support HER2 as validated biomarker and recently completed ongoing clinical trials HER2-directed agents in localized disease. Also reviewed mechanisms resistance for therapy research strategies including new imaging techniques studies patient-derived xenografts.
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