Association between five common polymorphisms in microRNA genes and the risk of gastric cancer: a meta-analysis.

摘要: Gastric cancer (GC) is a prevalent disease with high mortality rate, especially in developing countries. Accumulating evidence suggests that single nucleotide polymorphisms microRNA (miRNA) genes might influence the susceptibility to GC; such sequence variation contribute development of by altering crucial cellular pathways. In this study, we assessed correlation between miR-146a G>C, miR-196a-2 C>T, miR-499 T>C, miRNA-27a A>G, and miRNA-149 T>C GC. A comprehensive literature search for relevant studies published prior August 2014 was conducted using PubMed/Medline, Embase, Web Science, Cochrane Library, CNKI databases along Google Scholar. Meta-analysis performed odds ratios (ORs) 95% confidence intervals (CIs) as effect measures, incorporating 19 encompassing 8285 patients 10,716 controls. Allelic, dominant, recessive, homozygous, heterozygous genetic models were examined. Pooled results showed none five studied statistically related Stratified analyses ethnicity source controls miR- 146a G>C C>T. Subgroup analysis suggested G allele increase risk GC hospital-based case-control (HCC) but not population-based (HCC: recessive model: OR = 1.23, 95%CI 1.10-1.37, P < 0.001; 1.19, 1.06-1.34, 0.004). Overall, meta-analysis failed detect an association common gene susceptibility. However, does necessarily completely rule out miRNA