Analysis of circulating CD14+/CD16+ monocyte-derived macrophages (MDMs) in the peripheral blood of patients with oral squamous cell carcinoma
作者： Martin Grimm , Oliver Feyen , Johannes F. Coy , Heiko Hofmann , Peter Teriete
DOI: 10.1016/J.OOOO.2015.10.024
关键词:
摘要: Objectives Monocytes/macrophages are regarded as the first line of defense in tumors. Therefore, analyzing monocyte subtypes oral squamous cell carcinoma (OSCC) may be value disease monitoring and to explore immunotherapeutic strategies for cancer patients. Study Design Circulating peripheral blood CD14+/CD16+ monocyte-derived macrophages (MDMs) were evaluated OSCC patients with (n = 44) compared controls 85). Moreover, epitope detection monocytes (EDIM) technology was used detect biomarkers Apo10 transketolase-like-1 MDMs. Results Compared controls, no significant (P = .3646) difference (control group 9.8%, 8.8%) MDM noted OSCC. However, EDIM-Apo10 EDIM-TKTL1 scores detected MDMs increased (P Conclusions Analyzing represents a stable population detecting monitoring.
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