Radiation damage studies in cardiac muscle cells and tissue using microfocused X-ray beams: experiment and simulation.

摘要: Soft materials are easily affected by radiation damage from intense, focused synchrotron beams, often limiting the use of scanning diffraction experiments to radiation-resistant samples. To minimize in on soft tissue and thus improve data quality, needs be studied as a function experimental parameters. Here, impact X-ray hydrated cardiac muscle cells is investigated. It shown how small-angle signal upon variation scan parameters dose. The study was complemented simulations dose distributions for microfocused beams tissue. As simulation tool, Monte Carlo software package EGSnrc used that widely dosimetry research. Simulations also give additional guidance more careful planning distribution