Isothermal titration calorimetry in membrane protein research.
作者： Piotr Draczkowski , Dariusz Matosiuk , Krzysztof Jozwiak
DOI: 10.1016/J.JPBA.2013.09.003
关键词:
摘要: Isothermal titration calorimetry is a versatile method to characterize energetics of intermolecular reactions and in particular interactions between drug molecules their macromolecular targets. The assay widely used medicinal chemistry quantification characterization molecular mechanisms these interactions. article reviews applications the study ligand with various classes embedded membrane proteins. These proteins constitute very important fraction targets for compounds current therapies recently emerged detailed structural, functional biochemical molecules.
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