Assessing liver function by liver enhancement during the hepatobiliary phase with Gd-EOB-DTPA-enhanced MRI at 3 Tesla
作者： N Verloh , M Haimerl , F Zeman , M Schlabeck , A Barreiros
DOI: 10.1007/S00330-014-3108-Y
关键词:
摘要: The purpose of this study was to evaluate the usefulness Gd-EOB-DTPA-enhanced 3-T MRI determine hepatic functional reserve expressed by model for end-stage liver disease (MELD) score. A total 121 patients with normal function (NLF; MELD score ≤ 10) and 29 impaired (ILF; score > 10) underwent contrast-enhanced a hepatocyte-specific contrast agent at 3T. T1-weighted volume interpolated breath-hold examination (VIBE) sequences fat suppression were acquired before 20 min after injection. Relative enhancement (RE) between plain signal intensity calculated used Gd-EOB-DTPA uptake into parenchyma different scores. RE differed significantly (p ≤ 0.001) NLF (87.2 ± 29.5 %) ILF (45.4 ± 26.5 %). optimal cut-off value differentiate from 47.7 % (AUC 0.87). This showed sensitivity 82.8 % specificity 92.7 % differentiation analysed groups. in hepatocytes is strongly affected function. assessment during hepatobiliary phase (HBP) may serve as useful image-based test imaging determining regional global
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