CR1 and CR2: Receptors Mediating Cellular Recognition in the Complement System

摘要: Publisher Summary The complement system is a mechanism for the recognition of microorganisms that proceeds through two phases, first being covalent attachment proteins—C3 and C4—to other proteins to carbohydrates are part complement-activating complex, second phase receptor-mediated binding these complexes by various cell types, such as lymphocytes phagocytes. Activation C4 proteolytic enzyme, C1s, releases C4a peptide from α-chain, inducing major conformational alteration C4b fragment exposes or catalyzes transacylation reaction involving an internal thiolester in α-polypeptide. Attachment C3b after activation C3 convertases either pathway occurs same mechanism: release C3a α-polypeptide C3, causing change activates thiol ester induces —OH groups. containing covalently bound fragments cells having receptors specific fragments. This chapter explains structure/function relationships CR1 CR2 presents novel approach antiinflammatory therapy employs recombinant soluble form CR1. It also discusses relationship between natural ligand-binding site Epstein–Barr virus.