Lack of seasonal variation in flow-mediated dilatation of the brachial artery in women with primary Raynaud's phenomenon and healthy controls.

摘要: Background: The aim of this study was to examine endothelium function and seasonal variations endoethelium in women with primary Ravnaud's phenomenon (RP) healthy controls. Patients methods: After a fast at least 8 hours we studied 21 patients RP (mean age 31.1 years mean duration 9.1 years) 22 controls 27.8 by use high resolution brachial artery sonography winter (December/January 2000) summer (July/August 2001). To exclude circadian all examinations were performed the late afternoon only. All subjects non-smokers. Confounding factors like serum glucose, HbAlc, lipid concentrations analyzed immediately before investigations. Nicotine contamination randomly hair samples each group. Flow mediated dilatation (FMD%) nitroglycerin induced (NID%) calculated putting basal vessel diameter as 100%. Results: Basal, flow-mediated, nitroglycerin-induced absolute diameters did not differ significantly between groups (p = 0.85). test conditions (basal, postocclusive, nitroglycerin-induced) always let same response 0.61) there no significant influence these 0.07). Compared FMD% slightly reduced 0.09). Analysis variance excluded relation group season 0.43). For NID% too, statistically differences found. Conclusions: We able show impaired or seasonally variant flow-mediated RP. Our results argue against presence more generalized dysfunction detectable ultrasound