Femtosecond structural dynamics drives the trans/cis isomerization in photoactive yellow protein.
作者： K. Pande , C. D. M. Hutchison , G. Groenhof , A. Aquila , J. S. Robinson
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摘要: A variety of organisms have evolved mechanisms to detect and respond light, in which the response is mediated by protein structural changes after photon absorption. The initial step often photoisomerization a conjugated chromophore. Isomerization occurs on ultrafast time scales substantially influenced chromophore environment. Here we identify associated with earliest steps trans-to-cis isomerization photoactive yellow protein. Femtosecond hard x-ray pulses emitted Linac Coherent Light Source were used conduct time-resolved serial femtosecond crystallography microcrystals over range from 100 femtoseconds 3 picoseconds determine dynamics reaction.
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