Melanoma biomolecules: independently identified but functionally intertwined

摘要: The majority of patients diagnosed with melanoma present thin lesions and generally these have a good prognosis. However, 5% early (< 1mm thick) will recurrence die within 10 years, despite no evidence local or metastatic spread at the time diagnosis. Thus, there is need for additional prognostic markers to help identify those that may be risk recurrent disease. Many studies several meta-analyses compared gene protein expression in melanocytes, naevi, primary an attempt find informative patients. although large number putative biomarkers been described, few molecules are when used isolation. best approach likely involve combination molecules. We believe one could analyze group interacting proteins regulate different aspects pathway. This because lesion expressing involved multiple stages metastasis more lead secondary disease than does not. review focuses on five - cell adhesion molecule (MCAM), galectin-3 (gal-3), matrix metalloproteinase 2 (MMP-2), chondroitin sulfate proteoglycan 4 (CSPG4) paired box 3 (PAX3). goal provide context around what known about contribution biology metastasis. Although each independently identified as biomarkers, it clear from our analyses closely linked other, intertwined roles biology.