Role of endocannabinoid system in dopamine signalling within the reward circuits affected by chronic pain.

摘要: The association between chronic pain, depression and anxiety has gained particular attention due to high rates of comorbidity. Recent data demonstrated that the mesolimbic reward circuitry is involved in pathology pain. Interestingly, circuit participates both pain perception relief. endocannabinoid system (ECS) emerged as a highly relevant player processing. Targeting ECS could become novel treatment strategy for patients. However, little known about underlying mechanisms action cannabinoids at intersection neurochemical changes circuits Because understanding benefits risks paramount, aim this review evaluate state-of-art knowledge involvement dopamine signalling within affected by