Aspermatogenesis in the guinea pig induced by testicular tissue and adjuvants.

摘要: The injection into the dorsal skin of a suspension guinea pig testis or spermia incorporated in water-in-oil emulsion containing killed mycobacteria induces aspermatogenesis pigs. injury begins with inhibition maturation and proceeds through degeneration exfoliation spermatids, spermatocytes, finally spermatogonia. These germinal cells pass from seminiferous tubules epididymis. process is not associated inflammation. No significant changes occur intertubular spaces Leydig do seem to be affected. seminal vesicles prostate remain normal. may begin 10 days it lasts for more than 5 months. lead atrophy fibrosis. Guinea pigs which receive their own adjuvants develop similar injury. "mitochondrial" fraction effective while repeated injections alcoholic extract emulsified paraffin oil cause aspermatogenesis. presence acid-fast bacilli seems essential production testicular lesions; antigen different sites ineffective. When replaced by liver kidney rabbit no damage occurs. spinal cord combined results allergic encephalomyelitis large proportion pigs, accompanied great loss weight. testes few these animals show varying degree brain administered subcutaneously incidence high, although is, general, mild. From standpoint mechanism, spermatogenesis occurs unrelated follows cells. Aspermatogenesis as well certain related gonad: abdominal cavity, subcutaneous tissue over abdomen, inguinal region. Antibodies fixing complement are demonstrable sera injected adjuvants. omitted titers low Although there correlation between complement-fixing titer, this causal relationship. neutralize hyaluronidase those immobilize have also been demonstrated