Determination of Sufentanil in Human Plasma by Capillary Electrophoresis and Gas Chromatography–Mass Spectrometry

摘要: Abstract A fast capillary electrophoretic method and a gas chromatographic - mass spectrometric were developed for the determination of sufentanil in human plasma. Spiked plasma samples patient prepared by liquid-liquid extraction. In analysis, both inorganic organic buffers tested with without surfactants, at various pHs. The final separation analysis time was performed 3–[N-morpholino]propanesulfonic acid solution pH 7.00, bubble cell UV detection 195 nm. sample derivatization, nonpolar column material fentanyl as internal standard. identification done electron impact mode. limit lower technique than electrophoresis UV, therefore more required electrophor...