The application of HIV molecular epidemiology to public health.

摘要: HIV is responsible for one of the largest viral pandemics in human history. Despite a concerted global response prevention and treatment, virus persists. Thus, urgent public health action, utilizing novel interventions, needed to prevent future transmission events, critical eliminating HIV. For planning prove effective successful, we need understand dynamics regional epidemics intervene appropriately. molecular epidemiology tools as implemented phylogenetic, phylodynamic phylogeographic analyses have proven be powerful across many studies. Numerous applications with suggest that methods alone or combination mathematical modelling can provide inferences about dynamics, epidemiological parameters (prevalence, incidence, number infections, Re, generation times, time between infection diagnosis), spatiotemporal characteristics epidemics. Molecular been used assess impact an intervention outbreak investigation which are great relevance. In some settings, sequence data may more readily available than surveillance data, therefore allow conducted easily. Nonetheless, classic integral role monitoring evaluation programmes, should supplement emerging techniques from field epidemiology. Importantly, remains promising approach responding diseases.