Cytomegalovirus and Epstein-Barr virus subtypes--the search for clinical significance.

摘要: Cytomegalovirus (CMV) as well Epstein Barr virus (EBV) genomes include regions which show in part substantial polymorphisms. Characterization of several polymorphic led to the identification various CMV and EBV subtypes. Within last years there have been undertaken numerous efforts find out whether diverse subtypes differentially contribute clinical manifestations. However, although some associations described so far between a certain subtype development individual diseases these analyses were greatly complicated by huge genomic background EBV, large variety host–virus relations differences geographic or demographic distribution. In addition, it was shown meanwhile that proportion infections is due mixed with different this review we will give an overview current knowledge concerning significance subtypes, defined characterization selected also focus on recent infection populations may be disadvantageous compared single infections.