Genetic alterations in ovarian cancer cells that might account for sensitivity to chemotherapy in patients.
作者： Faina Vikhanskaya , Massimo Broggini
DOI: 10.1016/S0074-7696(02)19013-9
关键词:
摘要: The cellular response to anticancer agent treatments is determined by many factors that could be altered in tumor cells. induction of apoptosis cancer cells thought important for the overall these Despite introduction new and potent agents, survival rate patients with ovarian remains poor. In general present a poor propensity undergo apoptosis, which one reasons this relatively observed clinic. Induction result activation repression pro- antiapoptotic genes, are regulated complex mechanisms. Many activate "survival" program escape disruption allow propagation. review we have analyzed role genetic alterations determining drug treatment.
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