Microfluidic devices to facilitate in-flow medium exchange, and tuneable size-based sorting, of microspheres

摘要: This thesis is focused on the manipulation of solid spheres and droplets with a particular focus medium exchange size based sorting. Two novel microfluidic devices are demonstrated. Firstly, exchanger capable transferring between two miscible liquids was developed. The primary phase extracted via series narrow perpendicular channels using pressure differential created by mismatched input flow rates. Complete mineral oil phases has been demonstrated along use device to create buffer region for chemical sphere curing alginate in stem cell encapsulation. offers simple passive at greater throughput than previously demonstrated. The second tuneable focusing that focuses inertial lift forces. Through compression channel width reduced such moved from an unfocused state into streams. Focusing 12μm streams achieved through dimension deformation. shown be up 88% ±1.1% when compressed whilst uncompressed only 51.4% ±2.1% spheres. deformation potential range tuning possible