IRF4 is modulated by CD40L and by apoptotic and anti-proliferative signals in Hodgkin lymphoma.
作者： Donatella Aldinucci , Barbara Rapanaâ , Karin Olivo , Debora Lorenzon , Annunziata Gloghini
DOI: 10.1111/J.1365-2141.2009.07945.X
关键词:
摘要: The effects of proliferative, apoptotic and anti-proliferative stimuli on interferon regulatory factor 4 (IRF4) expression by Reed-Sternberg (RS) cells were analysed using a panel Hodgkin lymphoma (HL)-derived cell lines. IRF4 expressed HL was consistently upregulated after CD40 engagement; downregulated agonistic anti-CD95 antibodies in the FAS-sensitive HDLM-2 treatment with Adriamycin Dacarbazine, two chemotherapic agents commonly used for treatment. These results demonstrated, first time, that up-modulated engagement, down-modulated signals, suggesting an involvement also pathobiology.
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