Specifying protein kinase C functions in melanoma.
作者： Mitchell F. Denning
DOI: 10.1111/J.1755-148X.2012.01015.X
关键词:
摘要: The protein kinase C (PKC) family of serine/threonine kinases is a heterogeneous group enzymes receiving and integrating signals involved in both normal melanocyte biology melanoma pathology. Alterations PKC enzyme expression activation contribute to the malignant phenotype oncogenic tumor suppressive roles. Delineating diverse often context-dependent functions melanocyte/melanoma key capitalize on these as drug targets. This review summarizes several with focus regulation function.
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