Alcohol-induced deterioration in primary antioxidant and glutathione family enzymes reversed by exercise training in the liver of old rats
作者： K. Mallikarjuna , K.R. Shanmugam , K. Nishanth , Ming-Chieh Wu , Chien-Wen Hou
DOI: 10.1016/J.ALCOHOL.2010.07.004
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摘要: Abstract Chronic alcohol consumption causes severe hepatic oxidative damage, particularly to old subjects by decreasing various antioxidant enzymes. In this study, we test the hypothesis that exercise training can protect aging liver against alcohol-induced damage. Two different age groups of Wistar albino rats (3 months young, n =24; 18 old, =24) were evenly divided into four groups: control (Con), trained (Tr, 23m/min 30min/day, 5 days/week for 2 months), ethanol drinking/treated (Et, 2.0g/kg b.w. orally), and plus (Tr+Et). We found significantly ( P
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