Infection and Inflammation Induce LDL Oxidation In Vivo

摘要: Abstract —Epidemiological studies have shown an increased incidence of coronary artery disease in patients with chronic infections and inflammatory disorders. Because oxidative modification lipoproteins plays a major role atherosclerosis, the present study was designed to test hypothesis that host response infection inflammation induces lipoprotein oxidation vivo. Lipoprotein measured 3 distinct models inflammation. Syrian hamsters were injected bacterial lipopolysaccharide (LPS), zymosan, or turpentine mimic acute infection, systemic inflammation, localized respectively. Levels oxidized fatty acids serum fractions by determining levels conjugated dienes, thiobarbituric acid–reactive substances, lipid hydroperoxides. Our results demonstrate significant increase dienes substances all models. Moreover, LPS zymosan produced 4-fold 6-fold diene hydroperoxide LDL fraction. also 17-fold content lysophosphatidylcholine is formed during LDL. Finally, isolated from animals treated significantly more susceptible ex vivo copper than saline-treated animals, 3-fold decrease occurred lag phase oxidation. These increases lipids Increased may promote atherogenesis could be mechanism for