A Cohort Study Comparing Women with Autism Spectrum Disorder with and without Generalized Joint Hypermobility

摘要: Reports suggest comorbidity between autism spectrum disorder (ASD) and the connective tissue disorder, Ehlers-Danlos syndrome (EDS). People with EDS broader of Generalized Joint Hypermobility (GJH) often present immune- endocrine-mediated conditions. Meanwhile, immune/endocrine dysregulation is a popular theme in research. We surveyed group ASD women with/without GJH to determine differences exophenotypes. 25 years or older were invited participate an online survey. Respondents completed questionnaire concerning diagnoses, symptom history, experiences pain, seizure history. (ASD/GJH) reported more conditions than their non-GJH counterparts (p = 0.001). Autoimmune especially prominent ASD/GJH 0.027). Presence immune-mediated symptoms co-occurred one another < 0.001–0.020), as did 0.001–0.045), irrespective group. Finally, numbers shared strong inter-relationship 0.001), suggesting potential system crosstalk. While our results cannot estimate comorbidity, they reinforce concepts etiological relationship GJH. have complex exophenotypes compared counterparts. Further, we discuss how regulates immune systems turn may modulate collagen synthesis, potentially leading higher rates this subpopulation.