Catalytic reduction of amides to amines by electrophilic phosphonium cations via FLP hydrosilylation.
作者： Alessandra Augurusa , Meera Mehta , Manuel Perez , Jiangtao Zhu , Douglas W. Stephan
DOI: 10.1039/C6CC06914B
关键词:
摘要: A catalytic methodology for the conversion of amides to amines is reported. Of 25 examples described, 14 involve reduction N-trifluoroacetamides corresponding trifluoroethylamines. These reductions are achieved by hydrosilylation amide mediated an electrophilic phosphonium cation (EPC) catalyst.
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