Genome Plasticity in Salmonella enterica and Its Relevance to Host-Pathogen Interactions

摘要: Genome plasticity in Salmonella was first detected enterica serovar Typhi. It has been observed a number of serovars since then. Mechanisms that can lead to alterations the genome include changes at single-nucleotide level, gene loss, and rearrangements. rearrangements including inversions translocations plasticity, contributing divergence strains. pathogenicity islands (SPIs) are large regions DNA, which most likely acquired as result horizontal transfer (HGT) often associated with virulence. The virulence plasmids strains contribute adaptation organism, some cases allow genes. appears expansion host range is linked lateral (LGT) genes involved host-pathogen interactions. A common theme for variable between diversity sugar metabolism, highlighting redundancy these systems. majority coding unique Enteritidis encode prophage-related functions. Although sequence S. Pullorum found be very similar those other serovars, genetic arrangement significantly different, three major one translocation Understanding phenomenon this species important characterize relationship variation adaptation, well ability cause relatively minor gastrointestinal disease or potentially life-threatening systemic fever.