Efficacy of lidocaine in preventing primary ventricular fibrillation within 1 hour after a 300 mg intramuscular injection. A double-blind, randomized study of 300 hospitalized patients with acute myocardial infarction.

摘要: Abstract The effectiveness of intramuscular lidocaine in preventing in-hospital primary ventricular fibrillation within 1 hour after injection the drug patients with acute myocardial infarction was assessed a double-blind randomized study performed 300 such admitted 6 hours infarction. Six 147 treated mg had compared 4 153 control subjects. Mood level who experienced 1.4 ± 0.7 μ g/ml (mean standard deviation) at time fibrillation, value not significantly different from that did experience fibrillation. Lidocaine blood levels latter were 1.9 1.1, 2.1 1.1 and 1.7 g/ml, respectively, 7,15,30 60 minutes injection. In this ineffective possibly because given dose, mg, prevented attainment adequate drug.