The Osaka FAD mutation E22Δ leads to the formation of a previously unknown type of amyloid β fibrils and modulates Aβ neurotoxicity

作者: Oxana Yu. Ovchinnikova , Verena H. Finder , Ivana Vodopivec , Roger M. Nitsch , Rudi Glockshuber

DOI: 10.1016/J.JMB.2011.02.049

关键词:

摘要: … the aggregation characteristics and neurotoxicity of … in vitro aggregation studies in which no fibril formation of synthetic Aβ … long amyloid beta protein secreted by familial amyloid beta …

参考文章(42)
Leticia Miravalle, Takahiko Tokuda, Roberto Chiarle, Giorgio Giaccone, Orso Bugiani, Fabrizio Tagliavini, Blas Frangione, Jorge Ghiso, Substitutions at Codon 22 of Alzheimer's Aβ Peptide Induce Diverse Conformational Changes and Apoptotic Effects in Human Cerebral Endothelial Cells Journal of Biological Chemistry. ,vol. 275, pp. 27110- 27116 ,(2000) , 10.1074/JBC.M003154200
Malene Jensen, Johannes Schr�der, Mari Blomberg, Benita Engvall, Johannes Pantel, Nobuo Ida, Hans Basun, Lars-Olof Wahlund, Egon Werle, Marek Jauss, Konrad Beyreuther, Lars Lannfelt, Tobias Hartmann, Cerebrospinal fluid Aβ42 is increased early in sporadic Alzheimer's disease and declines with disease progression Annals of Neurology. ,vol. 45, pp. 504- 511 ,(1999) , 10.1002/1531-8249(199904)45:4<504::AID-ANA12>3.0.CO;2-9
Marcus Fändrich, Jessica Meinhardt, Nikolaus Grigorieff, Structural polymorphism of Alzheimer Aβ and other amyloid fibrils Prion. ,vol. 3, pp. 89- 93 ,(2009) , 10.4161/PRI.3.2.8859
Takami Tomiyama, Tetsu Nagata, Hiroyuki Shimada, Rie Teraoka, Akiko Fukushima, Hyoue Kanemitsu, Hiroshi Takuma, Ryozo Kuwano, Masaki Imagawa, Suzuka Ataka, Yasuhiro Wada, Eito Yoshioka, Tomoyuki Nishizaki, Yasuyoshi Watanabe, Hiroshi Mori, A new amyloid β variant favoring oligomerization in Alzheimer's‐type dementia Annals of Neurology. ,vol. 63, pp. 377- 387 ,(2008) , 10.1002/ANA.21321
Marina D Kirkitadze, Margaret M Condron, David B Teplow, Identification and characterization of key kinetic intermediates in amyloid beta-protein fibrillogenesis. Journal of Molecular Biology. ,vol. 312, pp. 1103- 1119 ,(2001) , 10.1006/JMBI.2001.4970
N Suzuki, T. Cheung, X. Cai, A Odaka, L Otvos, C Eckman, T. Golde, S. Younkin, An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants Science. ,vol. 264, pp. 1336- 1340 ,(1994) , 10.1126/SCIENCE.8191290
Jessica Meinhardt, Carsten Sachse, Peter Hortschansky, Nikolaus Grigorieff, Marcus Fändrich, Aβ(1-40) Fibril Polymorphism Implies Diverse Interaction Patterns in Amyloid Fibrils Journal of Molecular Biology. ,vol. 386, pp. 869- 877 ,(2009) , 10.1016/J.JMB.2008.11.005
Angela D. Williams, Erik Portelius, Indu Kheterpal, Jun-tao Guo, Kelsey D. Cook, Ying Xu, Ronald Wetzel, Mapping Aβ amyloid fibril secondary structure using scanning proline mutagenesis Journal of Molecular Biology. ,vol. 335, pp. 833- 842 ,(2004) , 10.1016/J.JMB.2003.11.008
Woojin Kim, Michael H Hecht, None, Mutations Enhance the Aggregation Propensity of the Alzheimer's Aβ Peptide Journal of Molecular Biology. ,vol. 377, pp. 565- 574 ,(2008) , 10.1016/J.JMB.2007.12.079
Minna Groenning, Lars Olsen, Marco van de Weert, James M. Flink, Sven Frokjaer, Flemming S. Jørgensen, Study on the binding of Thioflavin T to β-sheet-rich and non- β-sheet cavities Journal of Structural Biology. ,vol. 158, pp. 358- 369 ,(2007) , 10.1016/J.JSB.2006.12.010