A new look at the plasma disappearance of sulfobromophthalein (BSP): correlation with the BSP transport maximum and the hepatic plasma flow in man.

摘要: In order to improve the clinical usefulness of plasma disappearance curve sulfobromophthalein (BSP), its components were analyzed in 26 control subjects, 28 patients with cirrhosis, and 13 cases miscellaneous liver abnormalities. The uncorrected initial rate (ki) was found discriminate best between patient groups. second exponential component (k2) linearly correlated transport maximum (Tm) on a double logarithmic plot, but appeared be independent estimated hepatic flow (EHPF). An interpretation this relationship possible, when based model having saturation kinetics for biliary excretion. first primarily determined by perfusion. These relationships may contribute better understanding more rational use dye excretion tests as measures function. data also add our knowledge about nature excretory defect cirrhosis.