Substrate specificity in the context of molecular chaperones

摘要: Molecular chaperones are one of the key players in protein biology and as such their structure mechanism action have been extensively studied. However substrate specificity molecular has not well investigated. This review aims to summarize what is known about recognition motifs so better understand means context chaperones. Available literature shows that majority broad range recognize non-native conformations proteins depending on hydrophobic and/or charged patches. Based these can select for early, mid or late folding intermediates. Another major contributor chaperone co-chaperones they interact with sub-cellular location expressed inducability expression. Some which only a few substrates reported. In case mode seems be specific structural complementarity between substrate. It concluded vast do show high degree but elements signal conformation modulated by function in. display exquisite e.g. mammalian heat shock 47 collagen interaction. © 2017 IUBMB Life, 69(9):647-659, 2017.