Leptin and the Control of Body Weight: A Review of Its Diverse Central Targets, Signaling Mechanisms, and Role in the Pathogenesis of Obesity

摘要: summaRy Although we have alluded to the fact that a vast number of peripheral and central signals contribute energy homeosta-sis, in this article focus specifically on leptin signal as an exemplary model body weight control. We review evidence challenging classic view acts primarily at ARC control satiety through melanocor-tin pathway. Instead updated picture is presented whereby distributed network intercommu-nicating neurons both physiological hedonic determinants satiety. discLosuRe The authors declared no conflict interest. © 2009 Obesity Society ReFeRences 1. Considine RV, Sinha MK, Heiman ML et al . Serum immunoreactive-leptin concentrations normal-weight obese humans. N Engl J Med 1996;334:292–295.2. Montague CT, Farooqi IS, Whitehead JP Congenital deficiency associated with severe early-onset obesity Nature 1997;387:903–908.3. Pelleymounter MA, Cullen MJ, Baker MB