Down-Regulation of D2 Dopamine Receptor and Increased Protein Kinase Cμ Phosphorylation in Aldosterone-Producing Adenoma Play Roles in Aldosterone Overproduction
作者： Hong-Wei Chang , Tzong-Shinn Chu , Hong-Yu Huang , Shih-Chieh Chueh , Vin-Cent Wu
DOI: 10.1210/JC.2006-2338
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摘要: Context: The mechanism associated with the overproduction of aldosterone by aldosterone-producing adenomas (APA) is unknown. Objective: objective study was to explore role D2 dopamine receptor (D2R) on synthesis and secretion clarify clinical importance this in APA. Results: D2R expression APA examined 24 patients much less than that nontumorous adrenal cortex. mRNA levels were inversely correlated CYP11B2 patient’s plasma concentration. Angiotensin II (AII)-stimulated human adrenocarcinoma cells (H295R) attenuated agonist, bromocriptine (BMC). BMC selectively AII-induced protein kinase C (PKC)-μ phosphorylation its translocation cell membrane. PKCμ-specific short-hairpin RNA significantly decreased secretion. al...
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