Organizational complexity of β-adrenergic receptor signaling systems.
作者： Irina Glazkova , Katrin Altosaar , Terence E. Hébert
DOI: 10.1016/B978-0-12-384921-2.00002-1
关键词:
摘要: Publisher Summary This chapter describes the organizational complexity of β-adrenergic receptor signaling systems. The presence unique components within particular pathways (e.g., G proteins with a specific subunit composition, effector molecules, or regulatory proteins) suggests that there are correspondingly structural determinants involved in signal transduction might serve as allosteric targets for therapeutic small molecule, peptidic, and/or peptidomimetic drugs greater specificity and fewer side effects. discusses complexes based on receptors (βAR). diversity regulated by different βAR subtypes along some basic notions about pharmacological efficacy have reframed ideas organization protein-coupled (GPCR) also recent data regarding structure receptor, including implications homo- heterodimerization cellular signaling.
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sci-hub.se 参考文章(188)
Qin Wang, Bashar K. Mullah, Janet D. Robishaw, Ribozyme Approach Identifies a Functional Association between the G Protein β1γ7 Subunits in the β-Adrenergic Receptor Signaling Pathway Journal of Biological Chemistry. ,vol. 274, pp. 17365- 17371 ,(1999) , 10.1074/JBC.274.24.17365
Takako Shiina, Akiko Kawasaki, Taku Nagao, Hitoshi Kurose, Interaction with β-Arrestin Determines the Difference in Internalization Behavior between β1- and β2-Adrenergic Receptors Journal of Biological Chemistry. ,vol. 275, pp. 29082- 29090 ,(2000) , 10.1074/JBC.M909757199
Scott A. Burchett, In through the out door: nuclear localization of the regulators of G protein signaling Journal of Neurochemistry. ,vol. 87, pp. 551- 559 ,(2003) , 10.1046/J.1471-4159.2003.02047.X
Gregory J. Digby, Pooja R. Sethi, Nevin A. Lambert, Differential dissociation of G protein heterotrimers. The Journal of Physiology. ,vol. 586, pp. 3325- 3335 ,(2008) , 10.1113/JPHYSIOL.2008.153965
Marino Zerial, Heidi McBride, Rab proteins as membrane organizers Nature Reviews Molecular Cell Biology. ,vol. 2, pp. 107- 117 ,(2001) , 10.1038/35052055
Brian D Hudson, Terence E Hébert, Melanie EM Kelly, Physical and functional interaction between CB1 cannabinoid receptors and β2‐adrenoceptors British Journal of Pharmacology. ,vol. 160, pp. 627- 642 ,(2010) , 10.1111/J.1476-5381.2010.00681.X
Søren G. F. Rasmussen, Hee-Jung Choi, Daniel M. Rosenbaum, Tong Sun Kobilka, Foon Sun Thian, Patricia C. Edwards, Manfred Burghammer, Venkata R. P. Ratnala, Ruslan Sanishvili, Robert F. Fischetti, Gebhard F. X. Schertler, William I. Weis, Brian K. Kobilka, Crystal structure of the human beta2 adrenergic G-protein-coupled receptor. Nature. ,vol. 450, pp. 383- 387 ,(2007) , 10.1038/NATURE06325
Tony Warne, Maria J. Serrano-Vega, Jillian G. Baker, Rouslan Moukhametzianov, Patricia C. Edwards, Richard Henderson, Andrew G. W. Leslie, Christopher G. Tate, Gebhard F. X. Schertler, Structure of a beta1-adrenergic G-protein-coupled receptor. Nature. ,vol. 454, pp. 486- 491 ,(2008) , 10.1038/NATURE07101
Bronwyn A. Evans, Masaaki Sato, Mohsin Sarwar, Dana S. Hutchinson, Roger J. Summers, Ligand-directed signalling at β-adrenoceptors British Journal of Pharmacology. ,vol. 159, pp. 1022- 1038 ,(2010) , 10.1111/J.1476-5381.2009.00602.X
Olav A. Gressner, Birgit Lahme, Monika Siluschek, Katharina Rehbein, Ralf Weiskirchen, Axel M. Gressner, Intracrine signalling of activin A in hepatocytes upregulates connective tissue growth factor (CTGF/CCN2) expression Liver International. ,vol. 28, pp. 1207- 1216 ,(2008) , 10.1111/J.1478-3231.2008.01729.X