Separation of Diastereomers by Capillary Zone Electrophoresis with Polymer Additives: Effect of Polymer Type and Chain Length

摘要: Diastereomeric derivatives of enantiomers are separated by capillary zone electrophoresis in nonchiral separation systems the presence linear polymers. These polymers significantly influence mobilities analytes as well stereoselectivity system. Three types polymers, poly(vinylpyrrolidone), poly(ethylene glycol), and poly(acrylamide), investigated to determine their on stereoselective diastereomeric α-amino acids obtained reaction with optically pure (+)-O,O'-dibenzoyl-L-tartaric anhydride. Differences found strength polymer effect effected migration order. Polymer chain length had no impact stereoselectivity.