Ionic liquid form of donepezil: Preparation, characterization and formulation development
作者： Hao Wu , Fang Fang , Lulu Zheng , Weijie Ji , Minghui Qi
DOI: 10.1016/J.MOLLIQ.2019.112308
关键词:
摘要: Abstract The aim of this study was to transform donepezil into ionic liquids (ILs) promote its skin permeability for developing a new delivery mode donepezil. Donepezil ILs were formed by pairing with docusate, ibuprofen and four unsaturated fatty acids. synthesized fully characterized thermal analysis, fourier infrared spectroscopy, nuclear magnetic resonance spectrometer analysis. Physicochemical properties, such as solubility partition coefficients, measured at 25 °C. potential toxicity evaluated against human neuroblastoma SH-SY5Y cells. In vitro Electrophorus electricus acetylcholinesterase inhibitory activity docking also conducted evaluate the effect on inhibition after formation ILs. Blood-Brain Barrier (BBB) Parallel Artificial Membrane Permeability Assay Skin carried out BBB permeability, respectively. Furthermore, drug-in-adhesive transdermal patches prepared explore feasibility delivery. Ionic α-linolenic docosahexaenoic acid more permeable through artificial membrane than free base donepezil, indicated 1.9- 1.55-fold increase in addition, loaded adhesive had advantage permeation compared corresponding patch. liquid provided versatile platform facilitate
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